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TAZOBACTAM SODIUM

Tazobactam sodium

CAS: 89785-84-2

Molecular Formula: C10H12N4NaO5S

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TAZOBACTAM SODIUM - Names and Identifiers

Name Tazobactam sodium
Synonyms cl307579
TAZOBACTAM SODIUM
Tazobactam sodium
TAZOBACTAM SODIUM SALT
2-alpha-methyl-2-beta-(1,2,3-triazol-1-ylmethyl)penam-3-alpha-carboxylicacid
4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,3-methyl-7-oxo-3-(1h-1,2,3
sodium (2S,3S)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide
[2s-(2α,3β,5α)]-3-methyl-7-oxo-3(1h,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide
3-methyl-7-oxo-3-(1h-1,2,3-triazol-1-ylmethyl)-,4,4-dioxide,sodiumsalt,(2s-(2-alpha,3-beta,5-alp4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicaci
CL-298741, YTR-830H, [2S-(2α, 3β, 5α)]-3-Methyl-7-oxo-3(1H,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide
CAS 89785-84-2
EINECS 685-629-4
InChI InChI=1/C10H12N4O5S.Na/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19;/h2-3,7-8H,4-5H2,1H3,(H,16,17);/q;+1/p-1/t7-,8+,10+;/m0./s1

TAZOBACTAM SODIUM - Physico-chemical Properties

Molecular FormulaC10H12N4NaO5S
Molar Mass323.28
Melting Point140-147°C
Boling Point77℃
Specific Rotation(α)α]/D 144±4°, c = 0.1 in H2O
Flash Point>110°(230°F)
Water SolubilitySoluble in water.Soluble in water and methanol.
Solubility H2O: 50 mg/mL, clear, colorless
AppearanceWhite powder
Colorwhite
Storage ConditionKeep in dark place,Inert atmosphere,2-8°C
StabilityHygroscopic
MDLMFCD00917472
UseIs an irreversible competitive β-lactamase inhibitor

TAZOBACTAM SODIUM - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk Codes36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36 - Wear suitable protective clothing.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany3
RTECSXI0191500

TAZOBACTAM SODIUM - Nature

Open Data Verified Data

Tazobactam sodiumsalt: Cio HU N4NaoS.CAS accession number [89785-84-2]. Amorphous solid, melting point> 170 °c (decomposition). Soluble in water, slightly soluble in methanol, ethanol, insoluble in acetone, ethyl acetate, ether.

Last Update：2024-01-02 23:10:35

TAZOBACTAM SODIUM - Preparation Method

Open Data Verified Data

with sulbactam as raw material, the carboxyl group was protected by alcoholization, and then reacted with sodium azide to introduce an azide group on the methyl group. Reaction with vinyl acetate to form a triazole compound, and finally the hydrogen is freed from the protecting group to give tazobactam. Alternatively, 6-APA (6-aminopenicillanic acid) is used as a raw material, which is subjected to diazotization, bromination, peracetic acid oxidation, and then alcoholization, and then debromination is carried out under the action of zinc. It is then reacted with the trimethylsilyltriazole compound, the triazole compound is introduced, the potassium permanganate is oxidized, and finally the sodium tazobactam is hydrolyzed.

Last Update：2022-01-01 08:52:36

TAZOBACTAM SODIUM - Use

Open Data Verified Data

Japan Dapeng (Taiho) company research and development. p-lactamase inhibitors. For clinically important beta-lactamases such as penicillinase produced by S. Aureus, Proteus, Bacteroides, the chromosome-mediated p-lactamases produced by Klebsiella pneumoniae have a strong inhibitory effect. The width of the enzyme spectrum and the intensity of inhibition of enzyme activity were better than those of clavulanic acid and sulbactam. Its low toxicity, good stability, strong inhibition of enzyme activity. For the treatment of a variety of bacteria including aerobic and anaerobic bacteria caused by infection, including lower respiratory tract infections, skin and abdominal infections.

Last Update：2022-01-01 08:52:36
TAZOBACTAM SODIUM
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Product Name: Tazobactam Sodium Salt Visit Supplier Webpage Request for quotation
CAS: 89785-84-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Tazobactam Sodium Salt Visit Supplier Webpage Request for quotation
CAS: 89785-84-2
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Tazobactam sodium Request for quotation
CAS: 89785-84-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Tazobactam Sodium Salt Visit Supplier Webpage Request for quotation
CAS: 89785-84-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
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TAZOBACTAM SODIUM
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